Key result
Co-treatment with tocotrienols and bran significantly inhibited bodyweight gain in high-fat diet-treated mice over eight weeks.
Why the study?
To clarify the relationship between obesity and oxidative brain injury by investigating brain antioxidant networks in high-fat diet-treated mice in the presence or absence of tocotrienols and bran.
Does co-treatment with tocotrienols and bran reduce bodyweight gain and oxidative brain injury in high-fat diet-treated mice?
Does co-treatment with tocotrienols and bran reduce bodyweight gain and oxidative brain injury in high-fat diet-treated mice?
Tocotrienols and bran exhibit anti-obesity effects by inhibiting bodyweight gain in high-fat diet-treated mice, without significantly altering brain antioxidant networks.
Does not support human supplementation for weight control; leaves open whether tocotrienol-bran combinations merit clinical trials.
Obesity is a serious public health issue in developed countries, and is known to increase the risk of several diseases such as diabetes, cardiovascular events and arteriosclerosis. These phenomena are closely correlated with oxidative damage. Recently, several lines of evidence have demonstrated that neurodegenerative diseases such as Alzheimer's and Parkinson's are also related to oxidative damage. To clarify the relationship between obesity and oxidative brain injury, we investigated brain antioxidant networks in high-fat (HF) diet-treated mice in the presence or absence of tocotrienols (T3s) and bran. Co-treatment with T3s and bran significantly inhibited bodyweight gain in HF diet-treated mice. Serum and cortex T3 levels, and brain antioxidant enzyme activities and protein expressions did not differ among the groups except for SOD protein expression in the cerebellum. Brain p-mTOR and p-Akt protein expressions, which are related to autophagy, did not differ among the groups. These results indicate that treatment with T3s for eight weeks had showed an anti-obesity effect in HF diet-treated mice. However, significant alterations in T3 levels were not observed in the serum and brain of mice.
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Fukui et al. (2019) studied Obesity. Tocotrienols (T3s) and bran vs. High-fat diet without tocotrienols and bran was evaluated on Bodyweight gain and brain antioxidant networks. Co-treatment with tocotrienols and bran significantly inhibited bodyweight gain in high-fat diet-treated mice over eight weeks.
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