Key result
Acutely administered melatonin (10 mg/kg) prevented oxidative damage in the lungs and brain of rats exposed to hyperbaric oxygen, maintaining levels similar to untreated controls.
Why the study?
Does melatonin prevent oxidative damage in lung and brain induced by hyperbaric oxygen in rats?
Population
Rats exposed to 4 atmospheres of 100% oxygen for 90 min
Comparison
Melatonin injected immediately before the 90-min… vs Untreated control animals and animals exposed to…
Design
Preclinical
Follow-up
90 minutes
Authors
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Suggests potential adjunctive role for melatonin in hyperbaric oxygen therapy; leaves open translation beyond rodent models.
Does melatonin prevent oxidative damage in lung and brain induced by hyperbaric oxygen in rats?
Acutely administered melatonin prevents hyperbaric oxygen-induced oxidative damage in the lungs and brain of rats.
Pablos et al. (1997) studied Hyperbaric oxygen-induced oxidative damage. Melatonin vs. Untreated control animals was evaluated on Oxidative damage (lipid peroxidation products, antioxidative enzymes, and glutathione status). Acutely administered melatonin (10 mg/kg) prevented oxidative damage in the lungs and brain of rats exposed to hyperbaric oxygen, maintaining levels similar to untreated controls.
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