Key result
Among 5,487 Asian Indians, 25% had vitamin B12 deficiency, and 50% of those deficient individuals exhibited clinically high homocysteine levels, indicating a strong correlation.
Why the study?
Vitamin B complex levels correlate with homocysteine, but findings on whether supplementation lowers cardiovascular risk are conflicting.
Are levels of vitamin B6, folate, and B12 associated with homocysteine levels in Asian Indians?
Observational (n=5,487)
Are levels of vitamin B6, folate, and B12 associated with homocysteine levels in Asian Indians?
Vitamin B12 deficiency is strongly correlated with elevated homocysteine levels in Asian Indians, with a significantly higher prevalence in males.
B12 status correlated with homocysteine but not B6 or folate; supports targeted screening yet leaves open supplementation effects on CV outcomes.
Background: Vitamin B complex levels have been strongly correlated with homocysteine status and many studies suggest supplementation with vitamin B to lower cardiovascular risk among adults. However, this relationship does not show a direct trend with many studies concluding otherwise. Aims and Objective: Our report is an attempt to study association between levels of vitamin B6, folate and B12 in relation to homocysteine in a Pan-India cohort of over 5000 individuals. Materials & Methods: Data from a total of 5487 Asian Indians including 2942 males and 2545 females were considered for this study. Analysis for levels of vitamins B6 and folate was done using the technology of Liquid Chromatography - Mass Spectrometry (LC-MS), while that for Vitamin B12 and homocysteine was done using the Chemiluminescence Immunoassay (CLIA). Results: Our analysis identified a clear correlation between vitamin B12 status and levels of homocysteine, while no such trend was observed with vitamin B6 and folate. The total frequency of vitamin B12 deficiency was detected to be 25% of which 50% exhibited clinically high homocysteine levels. The frequency among males was found to be high at 61.6% in comparison to females at 32.3% with the difference being statistically significant at p<0.0001. Conclusion: Our report is one of the first few to document levels of vitamin B6, folate and B12 in relation to homocysteine in a large Asian Indian cohort. Low levels of vitamin B12 was found to have a greater impact on Hcy levels in comparison to other B-vitamins studied.
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Iyer et al. (2019) conducted an observational in Vitamin B deficiency and hyperhomocysteinemia (n=5,487). Vitamin B12, B6, and folate levels vs. Normal vitamin levels was evaluated on Clinically high homocysteine levels in patients with vitamin B12 deficiency. Among 5,487 Asian Indians, 25% had vitamin B12 deficiency, and 50% of those deficient individuals exhibited clinically high homocysteine levels, indicating a strong correlation.
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