Key result
Cardiac injury was independently associated with a significantly higher risk of in-hospital mortality (HR 2.06) among patients infected with avian influenza A (H7N9) virus.
Why the study?
The study was conducted to evaluate the prevalence of cardiac injury and its association with mortality in hospitalized patients infected with avian influenza A (H7N9) virus.
Does cardiac injury increase mortality in hospitalized patients infected with avian influenza A (H7N9) virus?
Population
321 hospitalized patients with avian influenza A (H7N9) virus infection across 133 hospitals in mainland China
Comparison
Cardiac injury vs no cardiac injury (uninjured group)
Design
Multicenter retrospective cohort study
Authors
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Cardiac injury was associated with higher H7N9 mortality; leaves open whether monitoring or intervention alters outcomes in future outbreaks.
Cohort (n=321)
Yes
Does cardiac injury increase mortality in hospitalized patients infected with avian influenza A (H7N9) virus?
Hazard Ratio: 2.06 (95% CI 1.31–3.24)
Absolute Event Rate: 64% vs 20.3%
p-value: p=<0.001
Cardiac injury is highly prevalent (63.2%) in patients hospitalized with avian influenza A (H7N9) and is independently associated with a twofold increased risk of in-hospital mortality.
Gao et al. (2020) conducted a cohort in Avian influenza A (H7N9) virus infection (n=321). Cardiac injury vs. No cardiac injury was evaluated on In-hospital mortality (HR 2.06, 95% CI 1.31-3.24, p=<0.001). Cardiac injury was independently associated with a significantly higher risk of in-hospital mortality (HR 2.06) among patients infected with avian influenza A (H7N9) virus.