Bladder Disturbance Due to Apresoline

THE usefulness of I-hydrazinophthalazine (Apresoline) in lowering the blood pressure of hypertensive patients is well established.1 However, side effects have been observed, such as occipital headache, tachycardia, palpitation, dizziness, weakness, nausea, vomiting, as well as (less frequently), numbness and tingling of the extremities, flushing, varying degrees of nasal congestion, lacrimation and conjunctival inflammation. Rarely, skin rash and fever have been reported.2 As therapy with Apresoline is continued, these side effects generally subside and are persistently troublesome enough to cause discontinuance of therapy in only a few cases.This report describes the part that Apresoline may play in causing difficulty in . . .