Key result
Sputum periostin concentrations were significantly higher in asthmatic patients than controls, with a cutoff of >528.25 ng/ml differentiating severe from mild-to-moderate asthma.
Why the study?
Asthma is heterogeneous, requiring personalized approaches for refractory disease, and periostin is a promising biomarker for predicting severity, prognosis, and potential therapeutic targeting.
Does sputum periostin level correlate with asthma severity and inflammatory phenotypes in adult asthmatic patients?
Observational (n=106)
Does sputum periostin level correlate with asthma severity and inflammatory phenotypes in adult asthmatic patients?
Sputum periostin is a promising biomarker that correlates with asthma severity and eosinophilia, helping to differentiate severe from mild-to-moderate asthma.
Sputum periostin may support severity stratification in asthma; leaves open its clinical utility as a routine biomarker pending prospective studies.
INTRODUCTION: Asthma is a common chronic inflammatory air way disease which poses a high disease burden worldwide. Asthma is a heterogenous disease with various phenotypes and endotypes. Refractory asthma requires new and personalized approaches to manage it effectively. Periostin is a promising biomarker that may help in predicting severity, prognosis and could be a therapeutic target. We aimed in this study to investigate periostin levels in the sputum of asthmatic Egyptian patients of inflammatory phenotypes and its relation to asthma severity. SUBJECTS AND METHODS: This study included 96 adult asthmatic patients; 48 patients with mild-to-moderate bronchial asthma, 48 patients with severe bronchial asthma according to ATS criteria and 10 healthy controls. All participants were subjected to full history taking and clinical examination; pulmonary function tests; skin prick test; induced-sputum analysis for inflammatory cells and periostin. RESULTS: Sputum periostin concentrations were significantly higher in patients with asthma than in controls. Sputum periostin is strongly correlated with age and sputum TLC and inversely correlated with FEV1. It is correlated with sputum neutrophil count and sputum eosinophil percentage. Best cut off value for sputum periostin is >528.25 ng/ml to differentiate between mild-to-moderate and severe asthma. CONCLUSION: Sputum periostin levels provide a satisfying diagnostic accuracy in severe asthmatic with persistent airflow limitation than mild-to-moderate asthmatic adults. There is a modest positive correlation between sputum periostin and sputum eosinophilia.
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Refaat et al. (2020) conducted an observational in Asthma (n=106). Sputum periostin vs. Healthy controls was evaluated on Sputum periostin concentrations. Sputum periostin concentrations were significantly higher in asthmatic patients than controls, with a cutoff of >528.25 ng/ml differentiating severe from mild-to-moderate asthma.
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