Key result
Coxsackie B4 and EMC viruses produced extensive damage to myocardial capillaries, coronary arteries, and the aorta in mice, with similar atherosclerotic-like changes observed in a human case.
Population
Random-breed suckling and 12-day-old HaM/ICR mice, and one 19-year-old male human patient with Coxsackie B4…
Comparison
Intraperitoneal inoculation with Coxsackie B4… vs Normal uninfected mice.
Design
Preclinical
Follow-up
24 hours to 10 days after inoculation (mice)
Authors
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Should not change clinical practice; leaves open viral initiation of human atherosclerosis pending prospective studies.
Viral infections such as Coxsackie B4 and EMC cause extensive vascular damage in mice and may be an initiating cause of arteriosclerosis in humans.
G.E. Burch (1975) studied Viral cardiomyopathy. Coxsackie B4 and EMC virus infection vs. Uninfected state was evaluated on Histological and ultrastructural changes in blood vessels. Coxsackie B4 and EMC viruses produced extensive damage to myocardial capillaries, coronary arteries, and the aorta in mice, with similar atherosclerotic-like changes observed in a human case.
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