Key result
Ageing and uraemia share striking analogies in their effects on central elastic arteries and the heart, including altered Windkessel function contributing to left ventricular hypertrophy.
Ageing and uraemia share striking pathophysiological similarities in their effects on central elastic arteries and the heart, contributing to left ventricular hypertrophy.
May inform shared mechanisms of LVH in CKD; leaves open whether targeting vascular stiffness alters outcomes.
The analogies between the effects of ageing and of uraemia on the function and the structure of central elastic arteries and of the heart are striking. Qualitatively similar changes are seen in pulse contour, pulse wave velocity, and impedance and also similar structural abnormalities with wall thickening, diminished elastin, and increased collagen content. The altered 'Windkessel' function of central arteries in age and uraemia is one factor contributing to left ventricular hypertrophy.
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Kerstin Amann (1998) conducted a review in Ageing and uraemia. Ageing and uraemia was evaluated. Ageing and uraemia share striking analogies in their effects on central elastic arteries and the heart, including altered Windkessel function contributing to left ventricular hypertrophy.
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