Key result
In anesthetized rats, nicorandil augmented the vasodepressor response to adenosine and CPCA, an effect mediated by activation of ATP-sensitive K+ channels linked to A2 receptor stimulation.
Why the study?
Does nicorandil potentiate adenosine A2 receptor-mediated vasodepression in anesthetized rats?
Population
Anesthetized rats
Comparison
Intravenous infusion of nicorandil or cromakalim… vs Adenosine or selective adenosine agonists alone…
Design
Preclinical
Authors
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May guide mechanistic studies of adenosine potentiation; leaves open human translation and clinical relevance.
Does nicorandil potentiate adenosine A2 receptor-mediated vasodepression in anesthetized rats?
Nicorandil augments adenosine-induced vasodepression through the activation of ATP-sensitive K+ channels linked to A2 receptor stimulation.
Saito et al. (1998) studied this question. Nicorandil was evaluated on Systemic blood pressure (SBP) and heart rate (HR) responses. In anesthetized rats, nicorandil augmented the vasodepressor response to adenosine and CPCA, an effect mediated by activation of ATP-sensitive K+ channels linked to A2 receptor stimulation.
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