Key result
Plasma endothelin-1 levels were significantly higher in hemodialysis patients with congestive heart failure compared to those without (2.4 vs 1.3 pg/ml before dialysis, p<0.01), and did not decrease after hemodialysis.
Why the study?
Are plasma endothelin-1 levels elevated and correlated with plasma renin activity in hemodialysis patients with chronic heart failure?
Cross-Sectional (n=31)
No
Are plasma endothelin-1 levels elevated and correlated with plasma renin activity in hemodialysis patients with chronic heart failure?
Absolute Event Rate: 2.4% vs 1.3%
p-value: p=<0.01
Plasma endothelin-1 is significantly elevated in hemodialysis patients with heart failure and correlates with plasma renin activity, suggesting an interaction between ET and PRA in the pathophysiology of heart failure in this population.
Elevated endothelin-1 associates with heart failure in hemodialysis patients; hypothesis-generating and requires prospective confirmation before any clinical role.
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Maruyama et al. (2000) conducted a cross-sectional in Chronic renal failure on maintenance hemodialysis with or without congestive heart failure (n=31). Congestive heart failure vs. No congestive heart failure was evaluated on Plasma endothelin-1 (ET) levels before hemodialysis (pg/ml) (p=<0.01). Plasma endothelin-1 levels were significantly higher in hemodialysis patients with congestive heart failure compared to those without (2.4 vs 1.3 pg/ml before dialysis, p<0.01), and did not decrease after hemodialysis.
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