Multi-praseodymium-and-tungsten bridging octameric tellurotungstate and its 2D honeycomb composite film for detecting estrogen

ions. Furthermore, the 2D 1@DODA (dimethyldioctadecyl ammonium bromide = DODA·Br) honeycomb composite material was prepared. The honeycomb morphology of the 1@DODA composite material provides rich binding sites for electrodepositing Au nanoparticles to make Au/1@DODA electrodes. The aptamer of 17β-estradiol (E2) hormone can be grafted to the Au/1@DODA electrodes via Au-S bonding interaction to construct the Au/1@DODA aptamer biosensors. By virtue of the specific recognition interaction of aptamer and the electrochemical signal amplification function of methylene blue and cDNA, the Au/1@DODA aptamer biosensors can realize the electrochemical detection of E2. This finding not only offers an electrochemical biosensing platform for detecting E2, but also expands POM-based composite materials in the applications of clinical detection and biological analysis.