What question did this study set out to answer?

To evaluate the association between different stages of hepatitis B virus (HBV) infection and the risk of developing type 2 diabetes mellitus (T2DM).

January 20, 2015Hepatology Research

Hepatitis B virus infection status and risk of type 2 diabetes mellitus: A meta‐analysis

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Authors

JZJian ZhangKanazawa University YSYi ShenChinese Academy of Medical Sciences & Peking Union Medical College HCHui CaiFujian Medical University

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Implication

Meta-analysis reveals increased type 2 diabetes risk specifically in hepatitis B cirrhosis, indicating that advanced liver damage rather than viral infection alone drives diabetes development.

Key Points

To evaluate the association between different stages of hepatitis B virus (HBV) infection and the risk of developing type 2 diabetes mellitus (T2DM).
Systematically searched PubMed, Embase, and Ovid databases, assessing study quality with the adapted Newcastle-Ottawa Quality Assessment Scale.
Analyzed 15 studies (seven cohort, four case-control, and four cross-sectional) comprising 118,530 participants.
Calculated pooled odds ratios (OR) and 95% confidence intervals (CI) using fixed- or random-effects models.
Hepatitis B cirrhosis was associated with a nearly twofold higher risk of T2DM compared with non-HBV controls (OR 1.99, 95% CI, 1.08–3.65).
Compared with non-cirrhotic chronic hepatitis B, hepatitis B cirrhosis significantly increased the risk of T2DM (OR 1.74, 95% CI, 1.43–2.13).
Asymptomatic HBV carriers and non-cirrhotic chronic hepatitis B patients showed no significant increase in diabetes risk compared with uninfected controls.

Cite This Study

Zhang et al. (2015) studied this question.

synapsesocial.com/papers/6a9fd23e20bdbf3a879c97d6 https://doi.org/10.1111/hepr.12481

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Implication

Meta-analysis reveals increased type 2 diabetes risk specifically in hepatitis B cirrhosis, indicating that advanced liver damage rather than viral infection alone drives diabetes development.

Hepatitis B virus infection status and risk of type 2 diabetes mellitus: A meta‐analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Hepatitis B virus infection status and risk of type 2 diabetes mellitus: A meta‐analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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