Key result
Prostaglandins are used for labor induction and cervical ripening, whereas prostaglandin synthetase inhibitors for pre-term labor risk premature closure of the ductus arteriosus.
Population
Pregnant women and newborns
Design
Review
Authors
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Limits prostaglandin synthetase inhibitor use in preterm labor; leaves open safer tocolytics without ductal effects.
The therapeutic potential of prostaglandin synthetase inhibitors for pre-term labor is severely limited by the risk of fetal ductus arteriosus closure and subsequent pulmonary hypertension.
Murray D. Mitchell (1981) conducted a review in Pregnancy. Prostaglandins and prostaglandin synthetase inhibitors was evaluated. Prostaglandins are used for labor induction and cervical ripening, whereas prostaglandin synthetase inhibitors for pre-term labor risk premature closure of the ductus arteriosus.
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