Computational modeling reveals a 5.72-fold reduction in antisense oligonucleotide screening effort, indicating accelerated therapeutic design optimization.
, achieving a 5.72-fold reduction in screening effort compared to random selection. ASO Atlas provides the first systematic resource to rigorously evaluate hypotheses regarding key parameters in ASO design, including sequence composition, chemical modifications, and target region selection. Both ASO Atlas and OligoAI have been made freely accessible through an online web-tool with the aim of facilitating the accelerated optimization of ASO design.
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Hill et al. (2026) studied this question.
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