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September 8, 2026

Disease-Specific Associations of Physical Activity in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus.

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Authors

JMJustus MörstedtLLLev LipovskiyBGBen Graul

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Overview

Cross-sectional study uncovers distinct drivers of physical activity in rheumatoid arthritis and systemic lupus erythematosus, highlighting the need for disease-specific exercise strategies.

Key Points

  • To identify and compare shared and disease-specific clinical, functional, and psychological factors associated with physical activity levels in patients with rheumatoid arthritis and systemic lupus erythematosus.
  • Cross-sectional study analyzing 200 patients with rheumatoid arthritis and 94 with systemic lupus erythematosus recruited from a German university rheumatology outpatient clinic.
  • Physical activity was evaluated using the International Physical Activity Questionnaire Long Form alongside patient-reported outcomes for quality of life, comorbidities, and objective walking performance.
  • Multivariable logistic regression models were constructed to determine independent predictors of physical activity in each disease cohort.
  • Patients with rheumatoid arthritis had lower physical performance (p < 0.001) but achieved higher physical activity levels than those with systemic lupus erythematosus (p < 0.001).
  • Fibromyalgia was the sole independent predictor of lower physical activity in rheumatoid arthritis (OR = 0.001, 95% CI <0.001–0.289; p = 0.017), whereas no independent predictors were identified in systemic lupus erythematosus.
  • Self-reported physical activity moderately correlated with objective walking performance in both cohorts (rheumatoid arthritis: R² = 0.19; systemic lupus erythematosus: R² = 0.12).

Cite This Study

Mörstedt et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd78a58e84d0ff5b4645bhttps://doi.org/10.1159/nim/adxag003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1AB1584-HPR PHYSICAL ACTIVITY ASSESSMENT IN PATIENTS WITH RHEUMATIC DISEASES: A CASE-CONTROL STUDY2024
  2. 2Factors associated with physical activity engagement among adults with rheumatoid arthritis: A cross‐sectional study2019 · 20 citations
  3. 3Barriers to physical activity in patients with systemic lupus erythematosus in the UK2026
  4. 4Correlates of Physical Activity in Adults With Rheumatoid Arthritis: A Systematic Review2014 · 53 citations
  5. 5Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis2009 · 194 citations