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September 8, 2026Acta Oto-Laryngologica

Systemic inflammatory indices primarily reflect tumor burden rather than independently predict prognosis in HPV-associated oropharyngeal squamous cell carcinoma

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Authors

TKTomotaka KakubariHTHideyuki TakahashiTSTomohiro Shimizu

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Overview

Cohort study reveals systemic inflammatory indices reflect tumor burden without predicting survival in HPV-positive oropharyngeal cancer, highlighting limits of blood-based prognostic markers.

Key Points

  • To evaluate the prognostic utility of systemic inflammatory indices and examine their relationship with clinicopathological characteristics in HPV-associated oropharyngeal squamous cell carcinoma.
  • Included 99 patients with p16-positive, HPV-associated oropharyngeal squamous cell carcinoma.
  • Evaluated systemic inflammatory indices, including NLR, PLR, LMR, SII, PNI, CAR, SIRI, and AISI.
  • Assessed associations with clinical outcomes and clinicopathological parameters using Kaplan-Meier survival curves and Cox proportional hazards regression analyses.
  • Most systemic inflammatory indices were associated with overall survival and only NLR was associated with progression-free survival in univariate analysis, but none remained statistically significant in multivariate models.
  • All evaluated inflammatory indices correlated significantly with primary tumor burden (T classification), while exhibiting limited associations with nodal or distant metastatic stages.

Cite This Study

Kakubari et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd78a58e84d0ff5b46496https://doi.org/10.1080/00016489.2026.2726027
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