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September 8, 2026Orthodontics and Craniofacial Research

Effects of Clear Aligner Therapy on Quality of Life and Anxiety Levels: An Exploratory Study in Patients With Disabilities

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Authors

KMKelly Regina Micheletti‐CerqueiraLILuciana Tiemi Inagaki‐NomuraMNMariana Emi Nagata

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Overview

Prospective exploratory study reveals improved overall quality of life during clear aligner therapy in individuals with disabilities, suggesting feasibility for specialized orthodontic care.

Key Points

  • To evaluate the effects of clear aligner therapy on quality of life and anxiety levels in patients presenting with malocclusion and disabilities.
  • Enrolled 14 patients with malocclusion and disabilities receiving clear aligner therapy (Invisalign).
  • Evaluated quality of life and anxiety at baseline (T0), three months (T1), and six months (T2) using the WHOQoL-BREF and State-Trait Anxiety Inventory (STAI-T).
  • Analyzed within-group changes across time points using Friedman's test with post hoc pairwise comparisons and assessed domain correlations via Spearman's rank correlation.
  • Overall Quality of Life scores increased significantly from the three-month to the six-month follow-up (p = 0.0145).
  • Scores in the Environment domain decreased significantly at six months compared to baseline and three months (p = 0.0126).
  • Spearman's rank correlation analysis demonstrated significant associations between multiple domains of the WHOQoL-BREF and STAI-T (p < 0.05).

Cite This Study

Micheletti‐Cerqueira et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd7ab58e84d0ff5b467d4https://doi.org/10.1111/ocr.70178
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of aligners on patients’ oral health-related quality of life and anxiety: a prospective pilot study2024 · 6 citations
  2. 2Comparison of anxiety, pain, and quality of life in individuals with mild or moderate malocclusion between conventional fixed orthodontic treatment versus Invisalign: a randomised clinical trial2024 · 19 citations
  3. 3A longitudinal pilot study examining the influence of the orthodontic system chosen in adult patients (brackets versus aligners) on oral health-related quality of life and anxiety2024 · 9 citations
  4. 4ASSESSMENT OF MALOCCLUSION SEVERITY AND ITS PSYCHOSOCIAL IMPACT IN ADOLESCENTS WEARING CLEAR ALIGNERS2025
  5. 5Patient-Reported Oral Health-Related Experiences in Children and Adolescents Treated with Fixed Appliances or Clear Aligners: A Cross-Sectional Study2026