What does this research mean for the field?

Non-neoplastic skin lesions, particularly microbial infections, account for the vast majority of skin biopsies in tertiary care and predominantly affect the lower limbs, whereas neoplastic lesions are less common and primarily affect the head and neck. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To analyze the histomorphological patterns, anatomical distribution, and demographic trends of neoplastic and non-neoplastic skin lesions.

September 8, 2026Open Access

Histopathological Spectrum and Clinicopathological Correlation of Skin Lesions in a Tertiary Care Centre: A Cross-Sectional Study

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To analyze the histomorphological patterns, anatomical distribution, and demographic trends of neoplastic and non-neoplastic skin lesions.
Cross-sectional histopathological review of 260 skin lesion cases correlated with clinical data in a tertiary care hospital.
Lesions were categorized into non-neoplastic and neoplastic subtypes (benign, precancerous, intermediate, malignant) and analyzed by age, sex, and anatomical location using descriptive statistics.
Non-neoplastic lesions accounted for 81% of cases, led by microbial infections (28.09%, primarily tinea corporis), non-infective vesiculobullous/vesiculopustular conditions (21.90%), and erythematous, papular, and squamous diseases (20.47%).
Neoplastic lesions comprised 14% of cases; benign tumors predominated (61.11%, led by seborrheic keratosis at 37.5%), while malignant lesions were equally divided between basal cell carcinoma (50%) and squamous cell carcinoma (50%).
Non-neoplastic lesions most frequently presented on the lower limbs, whereas neoplastic lesions were predominantly located on the head and neck.

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Implication

Cross-sectional study reveals non-neoplastic conditions dominate skin biopsies while malignant tumors concentrate on the head and neck, highlighting the value of routine histopathology for diagnosis.

Cite This Study

Jarwani et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd7b758e84d0ff5b469a1 https://doi.org/10.21276/apalm.3906

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Implication

Cross-sectional study reveals non-neoplastic conditions dominate skin biopsies while malignant tumors concentrate on the head and neck, highlighting the value of routine histopathology for diagnosis.

Histopathological Spectrum and Clinicopathological Correlation of Skin Lesions in a Tertiary Care Centre: A Cross-Sectional Study

Key Points

Discussion

Implication

Cite This Study

Histopathological Spectrum and Clinicopathological Correlation of Skin Lesions in a Tertiary Care Centre: A Cross-Sectional Study

Key Points

Discussion

Implication

Cite This Study

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