What does this research mean for the field?

Neisseria meningitidis can present atypically in young infants with initial isolation from urine, which likely represents secondary hematogenous seeding from invasive meningococcal disease rather than a primary urinary tract infection. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To report an atypical presentation of invasive meningococcal disease manifesting with initial bacterial isolation from sterile urine in a young infant.

September 8, 2026MicroorganismsOpen Access

Isolation of Neisseria meningitidis Serogroup B from Urine in a 74-Day-Old Infant: A Case Report

View Full Paper

Ask AI

Bookmark

Authors

ASArgyro Siapika FKFevronia KolonitsiouUniversity of Patras VBVenetia BellouUniversity of Patras

Discussion

Member takes

Implication

Case report demonstrates rare urine isolation of Neisseria meningitidis in a febrile infant, indicating secondary hematogenous seeding during invasive disease.

Key Points

To report an atypical presentation of invasive meningococcal disease manifesting with initial bacterial isolation from sterile urine in a young infant.
Evaluated a 74-day-old previously healthy infant presenting with fever without an apparent localizing focus.
Obtained sterile diagnostic specimens via suprapubic aspiration for urine culture, blood cultures, and cerebrospinal fluid testing by culture and multiplex PCR.
Administered intravenous antimicrobial therapy with ceftriaxone and temporary meropenem alongside complement pathway testing.
Sterile urine culture unexpectedly grew Neisseria meningitidis serogroup B, followed by positive blood cultures confirming systemic meningococcal bacteremia.
Cerebrospinal fluid showed pathologic inflammatory markers but negative culture and PCR, confirming the urinary finding represented secondary hematogenous seeding.
Complement pathway screening was normal, intracranial complications were excluded via neuroimaging, and targeted antimicrobial therapy led to full clinical recovery.

Cite This Study

Siapika et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd7c658e84d0ff5b46ce1 https://doi.org/10.3390/microorganisms14091977

View Full Paper

Ask AI

Bookmark

Implication

Case report demonstrates rare urine isolation of Neisseria meningitidis in a febrile infant, indicating secondary hematogenous seeding during invasive disease.

Isolation of Neisseria meningitidis Serogroup B from Urine in a 74-Day-Old Infant: A Case Report

Discussion

Member takes

Implication

Key Points

Cite This Study

Isolation of Neisseria meningitidis Serogroup B from Urine in a 74-Day-Old Infant: A Case Report

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider