Prognostic nomogram incorporating dynamic SIRI score and clinical parameters to predict postoperative recurrence of endometrial cancer

This study aimed to investigate the prognostic significance of dynamic changes in the systemic inflammation response index (SIRI) for predicting endometrial cancer recurrence and to establish a predictive model for assessing patients’ recurrence-free survival (RFS). A total of 1,731 patients diagnosed with endometrial cancer who underwent surgical resection between January 2010 and December 2019 were reviewed. The analysis revealed that dynamic changes in SIRI from baseline to 3 months post-operation correlated with patient survival. Specifically, patients with a dynamic SIRI score > 0.2 had worse survival outcomes than those with a score ≤ 0.2. A nomogram incorporating dynamic SIRI showed greater accuracy in predicting RFS compared to existing risk stratification systems, allowing for stratification into high- and low-risk groups. Elevated dynamic SIRI scores indicate poor clinical outcomes in endometrial cancer, and the comprehensive prognostic model demonstrates superior predictive ability for RFS by integrating clinicopathological variables and dynamic inflammatory markers.