Review outlines diagnostic features of superficial lipomatous tumors, highlighting emerging variants to prevent misdiagnosis of atypical lesions.
Key Points
Review the histologic features, emerging diagnostic entities, and molecular alterations characteristic of superficial lipomatous neoplasms.
Synthesized current pathology literature regarding common, atypical, and malignant superficial soft-tissue lipomatous tumors.
Evaluated diagnostic criteria, morphologic variations, and molecular profiles that distinguish classic lipomas from newly recognized variants.
Noted that although most superficial lipomatous neoplasms are benign, fully malignant and atypical subtypes like well-differentiated or dedifferentiated liposarcoma can occur superficially and risk diagnostic omission.
Described the expanded morphologic and molecular criteria for emerging entities, including dysplastic lipoma, atypical spindle cell and pleomorphic lipomatous tumor, and lipoblastoma.