What does this research mean for the field?

Ethanolic extracts of Moringa oleifera leaves and Telfairia occidentalis pods, both individually and in combination, modulate liver marker enzymes and enhance hepatic antioxidant capacity in male Wistar rats, though Telfairia occidentalis may induce histological changes requiring further safety evaluation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the individual and combined effects of ethanolic extracts of Moringa oleifera leaves and Telfairia occidentalis pods on hepatic biochemical markers, oxidative stress parameters, and tissue histology in male Wistar rats.

September 8, 2026Open Access

Effects of Telfairia Occidentalis Pod and Moringa Oleifera Leaf Extracts on Liver Marker Enzymes and Oxidative Stress Parameters in Male Wistar Rats

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Authors

OEO.O. EzomohNiger Delta University MUMohammed Joseph Usman CAChukwuma Samuel Anakwe

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Implication

Experimental study finds Moringa oleifera and Telfairia occidentalis extracts modulate liver enzymes and enhance antioxidants in rats, highlighting therapeutic value but unclear safety.

Key Points

To evaluate the individual and combined effects of ethanolic extracts of Moringa oleifera leaves and Telfairia occidentalis pods on hepatic biochemical markers, oxidative stress parameters, and tissue histology in male Wistar rats.
Twenty-four male Wistar rats were randomly allocated into four groups (n=6 per group) for a 28-day oral administration protocol.
Treatment arms received either single extracts of M. oleifera or T. occidentalis at 200 mg/kg body weight, or a combination of both extracts at 100 mg/kg each daily.
Serum liver enzymes (ALT, AST, ALP, GGT), bilirubin, protein markers, antioxidant enzymes (SOD, CAT, GPx), malondialdehyde, and liver histopathology were evaluated across time points.
Individual extracts significantly decreased ALT, AST, and GGT activities starting from day 21 (p < 0.05) and total bilirubin on day 28, while ALP decreased significantly from day 21 with T. occidentalis alone.
All treatments significantly increased total protein, albumin, SOD, and CAT activities, whereas GPx activity increased significantly only in the combined-treatment group.
Histological examination revealed normal hepatic architecture following M. oleifera treatment, but structural alterations were observed in the T. occidentalis and combined-treatment groups.

Cite This Study

Ezomoh et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd80458e84d0ff5b4721d https://doi.org/10.5281/zenodo.22645971

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Implication

Experimental study finds Moringa oleifera and Telfairia occidentalis extracts modulate liver enzymes and enhance antioxidants in rats, highlighting therapeutic value but unclear safety.

Effects of Telfairia Occidentalis Pod and Moringa Oleifera Leaf Extracts on Liver Marker Enzymes and Oxidative Stress Parameters in Male Wistar Rats

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Implication

Key Points

Cite This Study

Effects of Telfairia Occidentalis Pod and Moringa Oleifera Leaf Extracts on Liver Marker Enzymes and Oxidative Stress Parameters in Male Wistar Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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