What does this research mean for the field?

For the management of moderate-to-severe psoriasis in Saudi Arabia, updated evidence-based guidelines recommend adopting PASI 90 as the primary treatment goal and utilizing specific biologic therapies for both adult and pediatric patients. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To update evidence-based clinical practice guidelines for the management of adult and pediatric patients with moderate-to-severe plaque psoriasis.

September 8, 2026Journal of Dermatological TreatmentOpen Access

Practical Saudi Guidelines on management of moderate-to-severe psoriasis: 2026 update

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Authors

MFMohammed Ibrahim FataniHera General Hospital YBYousef BinamerKing Faisal Specialist Hospital & Research Centre DADana AlessaKing Saud bin Abdulaziz University for Health Sciences

Discussion

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Implication

Clinical practice guideline recommends advanced biologics and higher clearance benchmarks in moderate-to-severe psoriasis, indicating improved disease management across adult and pediatric care.

Key Points

To update evidence-based clinical practice guidelines for the management of adult and pediatric patients with moderate-to-severe plaque psoriasis.
Conducted a systematic review of PubMed, EMBASE, and the Cochrane Library for evidence published between 2020 and 2026 using the GRADE methodology.
Formulated and analyzed 31 PICO questions addressing major clinical and therapeutic management decisions.
Established 27 evidence-based recommendations and 4 good-practice statements, establishing PASI 90 over PASI 75 as the primary therapeutic goal.
Recommended biologic therapies for adults—including IL-17, IL-23, IL-12/23, and TNF-α inhibitors—to optimize disease control.
Advised early biologic treatment initiation in pediatric patients, specifying etanercept, secukinumab, ixekizumab, and adalimumab as preferred agents.

Cite This Study

Fatani et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd81458e84d0ff5b47488 https://doi.org/10.1080/09546634.2026.2724623

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Implication

Clinical practice guideline recommends advanced biologics and higher clearance benchmarks in moderate-to-severe psoriasis, indicating improved disease management across adult and pediatric care.

Practical Saudi Guidelines on management of moderate-to-severe psoriasis: 2026 update

Discussion

Member takes

Implication

Key Points

Cite This Study

Practical Saudi Guidelines on management of moderate-to-severe psoriasis: 2026 update

Discussion

Member takes

Implication

Key Points

Cite This Study

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