What does this research mean for the field?

A newly synthesized benzanilide derivative acts as a potent VEGFR-2 inhibitor with superior in vitro anticancer activity compared to sorafenib, inducing apoptosis while exhibiting favorable pharmacokinetic and safety profiles. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To design, synthesize, and evaluate novel benzanilide derivatives targeting VEGFR-2-mediated tumor angiogenesis for cancer therapy.

September 8, 2026Future Medicinal Chemistry

Integrated in vitro and in silico evaluations of novel benzanilide derivatives as anticancer agents

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Authors

AMAhmed M. MetwalyAl-Azhar University HEHazem ElkadyTwitter (United States)WEWalid E. ElgammalAl-Azhar University

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Implication

In vitro and in silico study demonstrates potent VEGFR-2 inhibition by benzanilide derivatives in cancer cell lines, highlighting their potential as anticancer leads.

Key Points

To design, synthesize, and evaluate novel benzanilide derivatives targeting VEGFR-2-mediated tumor angiogenesis for cancer therapy.
Synthesized benzanilide derivatives and confirmed their molecular structures using spectroscopic methods.
Assessed in vitro cytotoxicity against MCF-7, MDA-MB-231, HepG-2, and HCT-116 cancer lines alongside WI-38 and WISH normal cell lines.
Performed molecular docking, in silico ADMET profiling, VEGFR-2 enzymatic inhibition assays, and apoptotic biomarker evaluations.
The lead compound demonstrated potent VEGFR-2 enzyme inhibition with an IC50 of 0.414 µM, proving superior to the reference inhibitor sorafenib (IC50 = 0.809 µM).
Mechanistic assays revealed induction of apoptosis via marked upregulation of Bax, Caspase-3, and Caspase-8, paired with downregulation of Bcl-2.
ADMET computational profiling showed favorable drug-like pharmacokinetic properties and acceptable safety margins.

Cite This Study

Metwaly et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd83b58e84d0ff5b47a4b https://doi.org/10.1080/17568919.2026.2727415

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Implication

In vitro and in silico study demonstrates potent VEGFR-2 inhibition by benzanilide derivatives in cancer cell lines, highlighting their potential as anticancer leads.

Integrated in vitro and in silico evaluations of novel benzanilide derivatives as anticancer agents

Discussion

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Implication

Key Points

Cite This Study

Integrated in vitro and in silico evaluations of novel benzanilide derivatives as anticancer agents

Discussion

Member takes

Implication

Key Points

Cite This Study

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