What does this research mean for the field?

Spatial multiomics technologies that profile genomics, epigenomics, proteomics, or metabolomics within intact tissues are rapidly advancing and provide a more comprehensive view of disease progression than spatially resolved transcriptomics alone. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review the evolving landscape of spatial multiomics technologies that profile genomics, epigenomics, proteomics, and metabolomics within intact tissues beyond conventional transcriptomic platforms.

September 8, 2026JCI InsightOpen Access

Spatial multiomics in biomedical research: advances beyond transcriptomics

View Full Paper

Ask AI

Bookmark

Authors

XMXinchen MaoShanghai Jiao Tong University ZCZhuo ChenShanghai Jiao Tong University EHEmily J. HwangYale University

Discussion

Member takes

Implication

Review highlights advances in spatial multiomics beyond transcriptomics across intact tissues, indicating a shift toward multi-layered molecular profiling in biomedical research.

Key Points

To review the evolving landscape of spatial multiomics technologies that profile genomics, epigenomics, proteomics, and metabolomics within intact tissues beyond conventional transcriptomic platforms.
Surveyed technical breakthroughs in spatial multiomics instrumentation, chemistry, and commercial platform availability.
Assessed improvements in tissue sample compatibility, emerging translational applications, and computational tools for spatial data integration.
Identified rapid advances in mapping non-transcriptomic modalities—including proteins, chromatin states, and metabolites—directly within intact spatial architectures.
Highlighted growing commercialization and novel bioinformatic workflows that resolve multi-layered molecular interactions driving disease progression.

Cite This Study

Mao et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd83b58e84d0ff5b47a63 https://doi.org/10.1172/jci.insight.206951

View Full Paper

Ask AI

Bookmark

Implication

Review highlights advances in spatial multiomics beyond transcriptomics across intact tissues, indicating a shift toward multi-layered molecular profiling in biomedical research.

Spatial multiomics in biomedical research: advances beyond transcriptomics

Discussion

Member takes

Implication

Key Points

Cite This Study

Spatial multiomics in biomedical research: advances beyond transcriptomics

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider