Key result
Omentin treatment reduced neointimal thickening and suppressed vascular smooth muscle cell growth after arterial injury in mice through AMPK-dependent mechanisms.
Why the study?
Does omentin prevent neointimal formation after arterial injury in mice?
Population
Wild-type mice subjected to arterial wire injury, vascular smooth muscle cells, and fat-specific human…
Comparison
Adenoviral vectors encoding human omentin… vs Control β-gal adenoviral vectors or wild-type…
Design
Preclinical
Authors
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No immediate clinical role; leaves open omentin as a therapeutic target for human vascular injury.
Does omentin prevent neointimal formation after arterial injury in mice?
Omentin attenuates neointimal formation after arterial injury and suppresses vascular smooth muscle cell growth via AMPK-dependent mechanisms, suggesting a potential target for preventing vascular disorders.
Uemura et al. (2014) studied Vascular injury. Omentin vs. control β-gal was evaluated on Neointimal thickening and vascular smooth muscle cell growth. Omentin treatment reduced neointimal thickening and suppressed vascular smooth muscle cell growth after arterial injury in mice through AMPK-dependent mechanisms.
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