Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases

Glioneuronal tumors (GNTs) are a diverse group of central nervous system (CNS) neoplasms that primarily affects children and young adults [6].Their histopathological diagnosis can be extremely challenging due to overlapping morphological features among the different (sub-)types.In recent years, the use of next-generation sequencing and DNA methylation arrays revealed a large spectrum of different types of GNTs that are often characterized by a unique