Key result
A single maximum cardiopulmonary exercise test significantly reduced central systolic blood pressure in the first hour post-exercise compared to baseline (-6.8 mmHg; 95% CI -9.9 to -3.7; P<0.001).
Why the study?
Physical exercise induces acute peripheral hypotensive effects, but its significance on central systolic blood pressure is missing.
Does a single maximum cardiopulmonary exercise test reduce central and peripheral systolic blood pressure during 24-hour monitoring in healthy young men?
Does a single maximum cardiopulmonary exercise test reduce central and peripheral systolic blood pressure during 24-hour monitoring in healthy young men?
Mean Difference: -6.8 (95% CI -9.9–-3.7)
p-value: p=<0.001
A single bout of maximal exercise induces an immediate and sustained reduction in central systolic blood pressure, differing from the delayed response seen in peripheral systolic blood pressure.
Postexercise cSBP dips earlier and longer than pSBP in healthy men; leaves open distinct vascular regulation and need for outcome trials before clinical use.
BACKGROUND: Central systolic blood pressure (cSBP), a measure of arterial stiffness, determines the afterload of the heart and provides greater prognostic significance regarding cardiovascular outcomes than peripheral systolic blood pressure (pSBP). Physical exercise is associated with an acute hypotensive effect on pSBP, but the significance of exercise on cSBP is missing. This study investigates the effect of a single exercise bout on pSBP and cSBP during a 24-hour ambulatory blood pressure monitoring (ABPM). METHODS: In 25 healthy male individuals (27.5±5.5 years) baseline pSBP and cSBP values were determined in a supine position using the oscillometric Mobil-O-Graph device. Afterward, they performed a maximum cardiopulmonary exercise test (CPET) on a bicycle ergometer. The 24-hour ABPM was launched 15 minutes after terminating CPET. RESULTS: Significant dipping of cSBP was found compared to baseline values in the first (-6.8 [-9.9 to -3.7] mmHg; P<0.001) second (-7.4 [-10.6 to -4.2] mmHg; P<0.001) and third hour (-6.4 [-11.5 to -1.3]; P=0.016) after exercise. Afterwards, cSBP continuously increases but remains significant reduced to baseline in the third (-6.4 [-11.5 to -1.3] mmHg; P=0.016), and fifth hour (-4.3 [-8.2 to -0.4] mmHg; P=0.033). There were only significant changes in pSBP compared to baseline values after 10 hours till the night period. The dipping pattern in the night period was similar in pSBP and cSBP. CONCLUSIONS: 24-h postexercise responses of pSBP and cSBP differs significantly. This suggests a different regulatory mechanism of exercise on the peripheral and central arteries that have further be elucidated.
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Goeder et al. (2019) studied Healthy (n=25). Maximum cardiopulmonary exercise test (CPET) vs. Baseline was evaluated on Change in central systolic blood pressure (cSBP) in the first hour post-exercise (MD -6.8 mmHg, 95% CI -9.9 to -3.7, p=<0.001). A single maximum cardiopulmonary exercise test significantly reduced central systolic blood pressure in the first hour post-exercise compared to baseline (-6.8 mmHg; 95% CI -9.9 to -3.7; P<0.001).
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