Key result
Female sex was associated with a higher prevalence of left ventricular hypertrophy compared to male sex (62.1% vs. 37.9%) among adults with chronic kidney disease.
Why the study?
LVH is the most common structural cardiac abnormality in CKD, but its prevalence across patient sex and CKD stages needed evaluation.
Observational (n=200)
No
Absolute Event Rate: 62.1% vs 37.9%
Left ventricular hypertrophy is highly prevalent in CKD patients, particularly in females at advanced stages, and is associated with multifactorial predictors including anemia and hyperphosphatemia.
LVH prevalence data by CKD stage and sex may aid risk stratification; leaves open need for prospective outcome trials before guiding therapy.
Background Chronic kidney disease (CKD) is a common medical problem. Left ventricular hypertrophy (LVH) is the most common structural cardiac abnormality associated with it. The aim of this study is to evaluate the prevalence of LVH in CKD patients, considering the sex of the patient and the stage of CKD of the patient. Patients and methods A prospective observational study was carried out in the Nephrology and Dialysis Unit of Assiut University Hospital. It included adult patients with CKD above 18 years old. Results The study included 200 patients with different stages of CKD. More than half of the patients (51.5%) had LVH. LVH was more prevalent in females than males (62.1 vs. 37.9%). LVH in females was more often observed at IV and V stages of CKD (61.6 and 51.4%). The blood pressure was significantly higher in patients with LVH, while the hemoglobin level was lower in them compared with the other group ( P <0.001). Multivariable logistic regression showed that age, patient sex, CKD duration, CKD stage, ultrafiltration rate in hemodialysis, low serum calcium, and high serum phosphorus levels were the predictors of LVH in CKD. Conclusion LVH is a common finding in CKD patients (51.5%). LVH in CKD is multifactorial in nature and may be sex specific. With the progression of CKD, the development of LVH in females may be related to anaemia and hyperphosphataemia. The predominant pattern of LVH in the female population was eccentric.
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Hamad et al. (2025) conducted an observational in Chronic kidney disease (CKD) (n=200). Female sex vs. Male sex was evaluated on Left ventricular hypertrophy (LVH). Female sex was associated with a higher prevalence of left ventricular hypertrophy compared to male sex (62.1% vs. 37.9%) among adults with chronic kidney disease.
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