Designing nanoparticle carriers for enhanced drug efficacy in photodynamic therapy

-PS NPs (PS were tightly confined into the silica matrix), we identified that both PS trapping-in/releasing from the silica nanocarriers and the Au plasmonic effect were responsible for the PS efficacy variation. The mechanistic study also disclosed that the different NP configurations would affect the cellular death pathway. These findings provide a general guideline for the design of NP-based PDT applications.