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Article1 February 1938AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATTEFFECTS OF TREATMENT ON RADIUM AND CALCIUM METABOLISM IN THE HUMAN BODY*JOSEPH C. AUB, ROBLEY D. EVANS, DARIUS M. GALLAGHER, DOROTHY M. TIBBETTSJOSEPH C. AUBSearch for more papers by this author, ROBLEY D. EVANSSearch for more papers by this author, DARIUS M. GALLAGHERSearch for more papers by this author, DOROTHY M. TIBBETTSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-8-1443 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1924 Blum, a dentist,1and in 1925, Hoffman1suggested that radium produced necrosis of the jaw. Our knowledge of the pernicious effects of stored radium salts in human beings dates essentially from the publications in 1925 of Castle, Drinker and Drinker2and also Martland3when necrosis of the jaw in workers who had absorbed radium salts was reported and discussed. Since that time, increasing numbers of similar cases have been recorded. Other abnormal clinical results of radium have been the appearance of severe anemias as well as a high percentage of osteogenic sarcoma, first described and discussed by Martland,3...Bibliography1. BLUM T: Osteomyelitis of the mandible and maxilla (footnote), Jr. Am. Dent. Assoc., 1924, ii, 802-805. HOFFMAN, F. L.: Radium (mesothorium) necrosis, Jr. Am. Med. Assoc., 1925, lxxxv, 961. Google Scholar2. CASTLEDRINKERDRINKER WBKRCK: Necrosis of the jaw in workers employed in applying a luminous paint containing radium, Jr. Indust. Hyg., 1925, vii, 371. Google Scholar3. MARTLANDCONLONKNEF HSPJP: Some unrecognized dangers in the use and handling of radioactive substances: with special reference to the storage of insoluble products of radium and mesothorium in the reticulo-endothelial system, Jr. Am. Med. Assoc., 1925, lxxxv, 1769. MARTLAND, H. S.: The occurrence of malignancy in radioactive persons, Am. Jr. Cancer, 1931, xv, 2435-2516. CrossrefGoogle Scholar4. EVANS RD: Radium poisoning. A review of present knowledge, Am. Jr. Pub. Health, 1933, xxiii, 1017. CrossrefGoogle Scholar5. THOMASBRUNER HEFH: Chronic radium poisoning in rats, Am. Jr. Roentgenol. and Radium Therapy, 1933, xxix, 641. Google Scholar6. SCHLUNDTFAILLA HG: The detection and estimation of radium in living persons. III. The normal elimination of radium, Am. Jr. Roentgenol, and Radium Therapy, 1931, xxvi, 265-271. Google Scholar7. AUBFAIRHALLMINOTREZNIKOFF JCLTASP: Lead poisoning, 1926, Williams and Wilkins Co., Baltimore. HUNTER, D., and AUB, J. C.: Lead studies. XV. The effect of the parathyroid hormone on the excretion of lead and of calcium in patients suffering from lead poisoning, Quart. Jr. Med., 1927, xx, 123-140. Google Scholar8. FLINNSEIDLIN FBSM: Parathormone in the treatment of "radium poisoning." A preliminary report, Bull. Johns Hopkins Hosp., 1929, xlv, 269-275. Google Scholar9. FLINN FB: Elimination of radium salts from the human body, Jr. Am. Med. Assoc., 1931, xcvi, 1763. CrossrefGoogle Scholar10. SCHLUNDTBARKERFLINN HHHFB: Detection and estimation of radium and mesothorium in living persons, Am. Jr. Roentgenol. and Radium Therapy, 1929, xxi, 345-354. Google Scholar11. CRAVERSCHLUNDT LFH: Parathyroid extract and viosterol treatment of radium poisoning, Jr. Am. Med. Assoc., 1935, cv, 959. CrossrefGoogle Scholar12. BAUERAUB WJC: Studies of inorganic salt metabolism. I. The ward routine and methods, Jr. Am. Dietetic Assoc., 1927, iii, 106-115. CrossrefGoogle Scholar13. FAIRHALL LT: Lead studies. XI. A rapid method of analyzing urine for lead, Jr. Biol. Chem., 1924, lx, 485-488. CrossrefGoogle Scholar14. FISKELOGAN CHMA: The determination of calcium by alkalimetric titration. II. The precipitation of calcium in the presence of magnesium, phosphate, and sulfate, with applications to the analysis of urine, Jr. Biol. Chem., 1931, xciii, 211. CrossrefGoogle Scholar15. EVANS RD: Apparatus for the determination of minute quantities of radium, radon, and thoron in solids, liquids and gases, Rev. Sci. Inst., 1935, vi, 99. CrossrefGoogle Scholar16. EVANS RD: Radium poisoning. II. The quantitative determination of the radium content and radium elimination rate of living persons, Am. Jr. Roentgenol. and Radium Therapy, 1937, xxxvii, 368. Google Scholar17. SEILVIOLGORDON HACHMA: The elimination of soluble radium salts taken intravenously and per os, Radium, 1915, v, 40. Google Scholar18. SCHLUNDTNERANCYMORRIS HJTJP: The detection and estimation of radium in living persons. IV. The retention of soluble radium salts administered intravenously, Am. Jr. Roentgenol. and Radium Therapy, 1933, xxx, 515-522. Google Scholar19. MINOTAUB ASJC: Lead studies. V. The distribution of lead in the organism, Jr. Indust. Hyg., 1924, vi, 125-158. Google Scholar20. BEHRENSBAUMANN BA: Zur Pharmakologie des Bleis: X. Mitteilung, Ztschr. f. d. ges. exper. Med., 1933, xcii, 251. Google Scholar21. LACASSAGNELATTESLAVEDAN AJJ: Études experimentale des effets biologique du polonium introduit dans l'organisme, Jr. de radiol. and d'electrol., 1925, xci, 67-82. Google Scholar22. CAMERONVIOL WHGH: Classification of the various methods employed in the internal administration of radium emanation and radium salts, Radium, 1915, iv, 57. Google Scholar23. CALHOUNHUDSONAUB JAJCJC: Unpublished data. Google Scholar24. AUB JC: The biochemical behavior of lead in the body, Jr. Am. Med. Assoc., 1935, civ, 87-90. CrossrefGoogle Scholar25. YOUNGTAYLORMERRITT AGFHHH: The distribution and excretion of mercury, Arch. Dermat. and Syph., 1930, xxi, 539. CrossrefGoogle Scholar26. SALANTMEYER WG: The elimination of radium from normal and nephrectomized animals, Am. Jr. Physiol., 1907, xx, 366. CrossrefGoogle Scholar27. VOGT EC: Roentgenologic diagnosis of lead poisoning in infants and children, Jr. Am. Med. Assoc., 1932, xcviii, 125-128. CrossrefGoogle Scholar28. PARKJACKSONKAJDI EADL: Shadows produced by lead in the x-ray pictures of the growing skeleton, Am. Jr. Dis. Child., 1931, xli, 485. Google Scholar29. AUBROBBROSSMEISL JCGPE: The significance of bone trabeculae in the treatment of lead poisoning. Lead studies. XVII, Am. Jr. Pub. Health, 1932, xxii. 825. CrossrefGoogle Scholar30. TIBBETTSAUB DMJC: Magnesium metabolism in health and disease. I. The magnesium and calcium excretion of normal individuals, also the effects of magnesium, chloride, and phosphate ions, Jr. Clin. Invest., 1937, xvi, 491. CrossrefGoogle Scholar31. REED CI: Symptoms of viosterol overdosage in human subjects, Jr. Am. Med. Assoc., 1934, cii, 1745. CrossrefGoogle Scholar32. MACLEOD JJ: Physiology in modern medicine, seventh edition, 1935, C. V. Mosby Co., St. Louis, page 537. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication September 27, 1937.From the Medical Laboratories of the Collis P. Huntington Memorial Hospital of Harvard University and the Physics Department of the Massachusetts Institute of Technology.This is No. XXIII in the series of papers entitled "Studies of Calcium and Phosphorus Metabolism." PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLAURISTON S. TAYLOR LECTURE: THE QUEST FOR THERAPEUTIC ACTINIDE CHELATORSMaximum Permissible Body Burdens and Concentrations of Plutonium: Biological Basis and History of DevelopmentRenal Excretion of Alkaline Earths**These studies have been supported by the National Institutes of Health (AM-02306 and GM-K3-2583).Alpha-Radioactivity of Human BloodBiologie der RadionuclideReferencesTherapeutische Möglichkeiten bei Inkorporation von RadioisotopenTherapeutische Möglichkeiten bei Inkorporation von RadioisotopenTHE PREVENTION OF TETANUSDIAGNOSTIC ENZYMOLOGYSerum alkaline phosphatase activity in diseases of the skeletal and hepatobiliary systemsThe effectiveness of oral ammonium chloride on increased excretion of radio-strontium in manEffects of Radium in ManLATE CLINICAL CHANGES FOLLOWING THE INTERNAL DEPOSITION OF RADIOACTIVE MATERIALS*WILLIAM B. LOONEY, M.D.The Use of Chelating Agents for Accelerating Excretion of Radioelements*Laboratoriumseinrichtungen, Arbeitsmethoden, StrahlenschutzmaßnahmenDISSOCIATION CONSTANTS OF RADIUM-ORGANIC ACID COMPLEXES MEASURED BY ION EXCHANGEHealth Hazards in Radiation WorkThe Tolerance of Man for Radioactive IsotopesEXTRINSIC FACTORSMercury Poisoning A Review of Present Knowledge 1 February 1938Volume 11, Issue 8Page: 1443-1463KeywordsAnemiaCalciumNecrosisPhosphorusSaltsSarcoma Issue Published: 1 February 1938 PDF DownloadLoading ...
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