Key result
Binding of fructose bisphosphate aldolase to F-actin-tropomyosin-troponin filaments produced major alterations in its kinetic parameters and rendered them Ca2+-sensitive.
The kinetic properties of aldolase are significantly altered and become calcium-sensitive upon binding to F-actin-tropomyosin-troponin filaments, which may be relevant to its function in muscle fibers.
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No immediate clinical implications; leaves open whether Ca2+-sensitive aldolase kinetics modulate cardiac energetics in vivo.
Walsh et al. (1977) studied this question. Binding to F-actin-tropomyosin-troponin filaments vs. Binding to F-actin or F-actin-tropomyosin filaments was evaluated on Kinetic parameters of fructose bisphosphate aldolase. Binding of fructose bisphosphate aldolase to F-actin-tropomyosin-troponin filaments produced major alterations in its kinetic parameters and rendered them Ca2+-sensitive.
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