The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

Courtney Luterbach; Ashley Boshe; Heather Henderson; Eric Cober; Sandra S. Richter; Robert A. Salata; Robert C. Kalayjian; Richard Watkins; Andrea M. Hujer; Kristine M. Hujer; Susan D. Rudin; Tatiana Domitrovic; Yohei Doi; Keith S. Kaye; Scott Evans; Vance G. Fowler; Robert A. Bonomo; David van Duin

doi:10.1093/ofid/ofy351

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Abstract

In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections.

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Luterbach et al. (2018) studied this question.

synapsesocial.com/papers/6a9fe5a637b74494d9ba543a https://doi.org/10.1093/ofid/ofy351

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The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

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The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

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