Key result
High-anxious individuals demonstrated significantly greater neural activations in the hippocampus, insula, and middle cingulate gyrus in response to inspiratory occlusions compared to low-anxious individuals.
Why the study?
Although cortical activation in response to inspiratory occlusions differs between high- and low-anxious individuals, the specific brain areas showing different activation patterns remained unknown.
Do high-anxious individuals demonstrate different brain activation patterns in response to inspiratory occlusions compared to low-anxious individuals?
Comparison
17 high-anxious vs 17 low-anxious individuals during transient inspiratory occlusions
Design
Functional magnetic resonance imaging cross-sectional study
Authors
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High-anxious adults showed greater hippocampal, insular and cingulate activation during inspiratory occlusion; leaves open whether these patterns amplify breathlessness or warrant targeted intervention.
Cross-Sectional (n=34)
No
Do high-anxious individuals demonstrate different brain activation patterns in response to inspiratory occlusions compared to low-anxious individuals?
p-value: p=<0.05
Higher anxious individuals show stronger recruitment of emotion-related cortical and subcortical brain areas during respiratory mechanosensation, highlighting the role of anxiety in breathlessness perception.
Chan et al. (2019) conducted a cross-sectional in Healthy adults (Anxiety and respiratory mechanosensation) (n=34). High anxiety vs. Low anxiety was evaluated on Cortical and subcortical neural activations (BOLD response) in response to inspiratory occlusions (p=<0.05). High-anxious individuals demonstrated significantly greater neural activations in the hippocampus, insula, and middle cingulate gyrus in response to inspiratory occlusions compared to low-anxious individuals.
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