Key result
Labor does not significantly alter the mRNA and protein expression of endothelial and inducible nitric oxide synthases or cGMP concentrations in human placental tissues at term.
Why the study?
Does labor alter the expression of nitric oxide synthase isoforms and cGMP concentration in human placental tissues?
Population
Human intrauterine tissues from pregnant women. Includes term placenta 'in labor' and 'not in labor'…
Comparison
Labor (spontaneous vaginal delivery at term) vs Not in labor
Design
Preclinical
Authors
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Placental NO signaling likely preserved in labor; leaves open effects on vascular tone or coagulation risk in term deliveries.
Cross-Sectional (n=22)
No
Does labor alter the expression of nitric oxide synthase isoforms and cGMP concentration in human placental tissues?
Absolute Event Rate: 1.6023% vs 1.5806%
Nitric oxide production in the human placenta is maintained during labor, which may contribute to the maintenance of placental vascular tone and protect against over-coagulation.
Kakui et al. (2003) conducted a cross-sectional in Pregnancy (n=22). Labor vs. Not in labor was evaluated on eNOS mRNA expression in placental tissues (eNOS/GAPDH). Labor does not significantly alter the mRNA and protein expression of endothelial and inducible nitric oxide synthases or cGMP concentrations in human placental tissues at term.
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