Key result
Birth fractures in Werdnig-Hoffmann disease, caused by in utero osteoporosis from decreased movement, healed uneventfully with immobilization in all three reported cases.
Why the study?
Does immobilization lead to healing of birth fractures in patients with Werdnig-Hoffmann disease?
Does immobilization lead to healing of birth fractures in patients with Werdnig-Hoffmann disease?
Immobilization is an effective treatment for birth fractures in patients with Werdnig-Hoffmann disease, which can be misdiagnosed as osteogenesis imperfecta.
May support immobilization for birth fractures in Werdnig-Hoffmann disease; hypothesis-generating and should not yet change practice.
Three patients with birth fractures and Werdnig-Hoffmann disease are presented. Two of the three were erroneously diagnosed as having osteogenesis imperfecta. The etiology of these fractures appears to be in utero osteoporosis secondary to decreased movement, leading to pathologic fracture during birth. Immobilization led to uneventful healing in all cases; no recurrent fractures were seen.
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Burke et al. (1986) studied this question. Birth fractures in Werdnig-Hoffmann disease, caused by in utero osteoporosis from decreased movement, healed uneventfully with immobilization in all three reported cases.
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