Key result
17beta-estradiol treatment starting prior to puberty (25 days old) significantly improved survival rate and reduced left ventricular dilatation in male mice with cardiomyopathy (p < 0.05).
Why the study?
Does 17beta-estradiol improve survival in male mice with TNF-alpha-induced cardiomyopathy?
Population
Male transgenic mice with congestive heart failure induced by cardiac-specific overexpression of tumor…
Comparison
17beta-estradiol treatment starting at 25 +/- 1… vs Untreated male TNF1.6 mice (control)
Design
Preclinical
Authors
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May benefit male TNF-alpha cardiomyopathy models when started pre-puberty; hypothesis-generating for human HF translation.
Does 17beta-estradiol improve survival in male mice with TNF-alpha-induced cardiomyopathy?
p-value: p=< 0.05
Pre-pubertal exposure to 17beta-estradiol improves survival and limits the severity of cardiomyopathy in a male mouse model of TNF-alpha-induced heart failure.
Kadokami et al. (2005) studied Congestive heart failure / cardiomyopathy. 17beta-estradiol (E2) vs. Untreated male TNF1.6 mice was evaluated on Survival rate (p=< 0.05). 17beta-estradiol treatment starting prior to puberty (25 days old) significantly improved survival rate and reduced left ventricular dilatation in male mice with cardiomyopathy (p < 0.05).
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