Synthesis of tethered bis-macrocycles by cross-coupling of N-(3,5-dibromobenzyl)azacrowns with α,ω-diamino compounds

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Palladium-catalyzed cross-coupling of N-(3,5-dibromobenzyl) derivatives of 1-aza-15-crown-5 and 1-aza-18-crown-6 with a,w-diamino compounds afforded macrocyclization products comprising two tethered different azacrowns.