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May 1, 1995Nucleosides and Nucleotides

Synthesis and Biological Activity of 5-Fluoro-2-thiocytosine Nucleosides

Maria Bretner Małgorzata Balińska Krzysztof Krawiec Borys Kierdaszuk David Shugar Tadeusz Kulikowski

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Abstract

Two pathways are described for the synthesis of the 2′-deoxynucleosides of 2-thiocytosine and 5-fluoro-2-thiocytosine: (a) by nucleoside condensation, (b) by amination of the corresponding nucleosides of 2,4-dithiouracil. Biological activities vs two cell systems are described. The nucleosides are moderate to weak substrates of deoxycytidine kinase and, partly as a result of this, reasonable good inhibitors of the enzyme

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Bretner et al. (1995) studied this question.

synapsesocial.com/papers/6a9fe8acec51e6b28b1de19e https://doi.org/10.1080/15257779508012445

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