Key result
Serine protease inhibitors Trasylol and soyabean trypsin inhibitor prevented the acid-activation of plasma inactive renin, indicating this process is mediated by an endogenous serine protease.
This basic science study demonstrates that the acid-activation of inactive renin in human plasma is mediated by a serine protease.
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Should not change clinical practice; leaves open serine protease targeting of inactive renin for mechanistic studies.
The protease inhibitors Trasylol and soyabean trypsin inhibitor prevented the activation of plasma inactive renin by acid. 2. N-Ethylmaleimide inhibited acid-activation to some extent but o-phenathroline had no effect. 3. Acid-activation of the inactive renin in human plasma is mediated by a serine protease.
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B Leckie (1978) studied this question. Serine protease inhibitors Trasylol and soyabean trypsin inhibitor prevented the acid-activation of plasma inactive renin, indicating this process is mediated by an endogenous serine protease.
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