Adrenaline enhances in vitro platelet activation and aggregation in blood samples from ticagrelor‐treated patients

Figure 1. Effect of adrenaline on adenosine diphosphate (ADP)‐induced platelet aggregation in blood samples from patients on ongoing treatment with acetylsalicylic acid and ticagrelor (n = 10). The concentrations are resulting plasma concentration of adrenaline in the blood samples. Boxes indicate 25th and 75th percentiles while the median is indicated by the line across the inside of the box. Whiskers denote the minimum and maximum values. **P < 0.01

Figure 2. Effect of addition of adrenaline (Adr) alone or in combination with platelet concentrate on adenosine diphosphate (ADP)‐induced platelet aggregation in blood samples from patients on ongoing treatment with acetylsalicylic acid and ticagrelor (n = 10). Boxes indicate 25th and 75th percentiles while the median is indicated by the line across the inside of the box. Whiskers denote the minimum and maximum values excluding outliers (values more than 1.5 times the interquartile range) and extreme points (values more than 3 times the interquartile range). Outliers are presented as dots. **P < 0.01

Figure 3. Effect of addition of adrenaline (Adr) alone, ADP HS test alone and combination of adrenaline with ADP HS test on platelet aggregation in blood samples from patients on ongoing treatment with acetylsalicylic acid and ticagrelor (n = 10). Boxes indicate 25th and 75th percentiles while the median is indicated by the line across the inside of the box. Whiskers denote the minimum and maximum values. *P < 0.05, **P < 0.01

Figure 4. Effect of addition of adrenaline (Adr) alone, ADP alone and the combination of ADP and adrenaline on PAC‐1 binding (binds to activated fibrinogen receptor) in blood samples from patients on ongoing treatment with acetylsalicylic acid and ticagrelor (n = 10). Boxes indicate 25th and 75th percentiles while the median is indicated by the line across the inside of the box. Whiskers denote the minimum and maximum values excluding outliers (values more than 1.5 times the interquartile range) and extreme points (values more than three times the interquartile range). Extreme points are indicated by the symbol ×. **P < 0.01

Figure 5. Effect of addition of adrenaline (Adr) alone, ADP alone and the combination of ADP and adrenaline on expression of platelet activation marker P‐selectin in blood samples from patients on ongoing treatment with acetylsalicylic acid and ticagrelor (n = 10). Boxes indicate 25th and 75th percentiles while the median is indicated by the line across the inside of the box. Whiskers denote the minimum and maximum values excluding outliers (values more than 1.5 times the interquartile range) and extreme points (values more than 3 times the interquartile range). Outliers are presented as dots. *P < 0.05, **P < 0.01