Key result
Adrenaline at low concentrations potentiates human platelet aggregation by adenosine diphosphate, an effect blocked by adrenergic alpha-receptor antagonists but not beta-receptor antagonists.
Why the study?
Does adrenaline potentiate adenosine diphosphate-induced aggregation in human blood platelets?
Population
Human blood platelets
Design
Preclinical
Authors
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May implicate alpha-receptors in catecholamine-driven thrombosis; leaves open translation from animal models to humans.
Does adrenaline potentiate adenosine diphosphate-induced aggregation in human blood platelets?
Adrenaline potentiates ADP-induced platelet aggregation via alpha-adrenergic receptors, highlighting the role of catecholamines in thrombosis.
Mills et al. (1967) studied In vitro human blood platelets. Adrenaline vs. Noradrenaline, isopropylnoradrenaline was evaluated on Platelet aggregation by adenosine diphosphate. Adrenaline at low concentrations potentiates human platelet aggregation by adenosine diphosphate, an effect blocked by adrenergic alpha-receptor antagonists but not beta-receptor antagonists.
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