Population
Washed rabbit platelets
Comparison
0.5 microM-ADP and 50 microM-adrenaline in… vs 0.5 microM-ADP alone or 50 microM-adrenaline alone
Design
Preclinical
Authors
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Alpha-adrenergic signaling may enhance platelet responses in models; leaves open relevance to human thrombosis or antiplatelet strategies.
Adrenaline potentiates ADP-induced platelet aggregation by enhancing the turnover of phosphatidylinositol 4-phosphate and degradation of phosphatidylinositol, mediated via alpha-adrenergic receptors.
Keraly et al. (1987) studied this question.
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