Key result
Intravenous aminophylline therapy showed no overall difference in spirometric values compared to control regimens for the treatment of severe, acute asthma.
Why the study?
Does intravenous aminophylline improve spirometric values in patients with severe, acute asthma compared to other bronchodilators?
Population
Patients with severe, acute asthma (13 controlled trials)
Comparison
Intravenous aminophylline therapy vs Albuterol, epinephrine, or other bronchodilators
Design
Meta-analysis
Authors
Loading...
Does not support routine IV aminophylline in severe acute asthma; challenges longstanding practice and warrants guideline reevaluation.
Meta-Analysis
Does intravenous aminophylline improve spirometric values in patients with severe, acute asthma compared to other bronchodilators?
Despite widespread practice, available trials do not provide adequate evidence to support or reject the use of aminophylline in the treatment of severe, acute asthma.
Benjamin Littenberg (1988) conducted a meta-analysis in severe, acute asthma. Intravenous aminophylline vs. albuterol (salbutamol), epinephrine, or other bronchodilators was evaluated on spirometric values. Intravenous aminophylline therapy showed no overall difference in spirometric values compared to control regimens for the treatment of severe, acute asthma.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: