Key result
Preoperative frailty, assessed by the 5-item modified frailty index, significantly increased the odds of 30-day postoperative complications (OR 3.88) in patients undergoing lung cancer surgery.
Why the study?
Lung cancer is anticipated to be the most common cancer in China, and the utility of the five-item modified frailty index (mFI-5) for predicting postoperative complications in lung cancer surgery required evaluation.
Does frailty assessed by the mFI-5 predict postoperative complications in adults with lung cancer undergoing surgery?
Cohort (n=541)
No
Does frailty assessed by the mFI-5 predict postoperative complications in adults with lung cancer undergoing surgery?
Odds Ratio: 3.88 (95% CI 1.94–7.73)
Absolute Event Rate: 28.6% vs 9.3%
p-value: p=<0.001
The mFI-5 is a pragmatic tool that can independently predict 30-day postoperative complications in patients undergoing lung cancer surgery.
mFI-5 may flag higher-risk lung cancer surgery patients; leaves open its value for risk stratification or care decisions.
Background: Lung cancer is anticipated to be the most common cancer in China. This study aimed to evaluate the utility of the five-item modified frailty index (mFI-5) as a predictor of postoperative complications in patients undergoing surgery for lung cancer. Methods: This retrospective cohort study was conducted in a tertiary hospital between January, 2020, and September, 2021. We included adults with lung cancer undergoing surgery and conducted bivariate statistical analyses using Fisher's exact test, chi-square test, and independent samples t-test. Logistic regression models were used for the multivariate analysis. Results: We included 541 patients (37.2% male, 62.8% female; mean age, 57.4 ± 10.4 years) with a prevalence of frailty of 9.06%. The presence of frailty was associated with higher complications according to the Clavien–Dindo classification (odds ratio: 3.88; 95% confidence interval: 1.94 − 7.73). The consistency of the regressions indicates the robustness of the results. Conclusion: Our study indicates that the mFI-5 based on data from medical records is a pragmatic tool that can independently predict postoperative complications in patients with lung carcinoma undergoing surgery. Upon further validation, integration of this tool into clinical practice may be beneficial for optimizing patient risk stratification.
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Li et al. (2023) conducted a cohort in Lung cancer (n=541). Frailty (mFI-5 ≥ 2) vs. Non-frailty (mFI-5 < 2) was evaluated on Postoperative complications within 30 days (Clavien-Dindo classification ≥ grade 2) (OR 3.88, 95% CI 1.94-7.73, p=<0.001). Preoperative frailty, assessed by the 5-item modified frailty index, significantly increased the odds of 30-day postoperative complications (OR 3.88) in patients undergoing lung cancer surgery.
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