Key result
A variety of experimental models of neural injury are advancing research into the mechanisms and potential treatments for glaucomatous optic neuropathy, despite no single model being perfect.
A variety of experimental models exist to study neural injury in glaucomatous optic neuropathy, though no perfect model currently exists.
Supports diverse experimental models for glaucoma research; leaves open identification of an optimal model for clinical translation.
A variety of methods can be used experimentally to model neural injury, and thus study the process that represents the major pathophysiology underlying glaucomatous optic neuropathy. These methods vary in difficulty, relevance to human glaucoma, and time course. There is no perfect model, partly because our understanding of the glaucomas is still incomplete. Nonetheless, research into the mechanisms underlying the optic neuropathy of glaucoma (as well as possible new treatments) is advancing rapidly because of the availability of a wide variety of models of neural injury.
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Leonard A. Levin (2001) conducted a review in Glaucomatous optic neuropathy. Experimental models of neural injury was evaluated. A variety of experimental models of neural injury are advancing research into the mechanisms and potential treatments for glaucomatous optic neuropathy, despite no single model being perfect.
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