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The respiratory enzyme cytochrome c oxidase (COX) is composed of subunits encoded by both nuclear and mitochondrial genes; thus, COX activity reflects, to some extent, the coordinated function of the two genomes. Because extensive mtDNA differentiation exists between populations of the copepod Tigriopus californicus, we hypothesized that laboratory hybridizations that disrupt natural combinations of nuclear and mitochondrial genes might negatively impact COX activity. Although experimental results varied greatly among different crosses, replicate sets of crosses between two particular populations showed consistent evidence for nuclear-cytoplasmic coadaptation.
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Edmands et al. (1999) studied this question.
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