Key result
Following primary immunization with 4 doses of DTaP-wIPV, the positive rate of IgG antibodies against pertussis toxin declined to 31.9% at 4 years of age, indicating waning immunity and suggesting the need for a preschool booster.
Why the study?
Does primary immunization with DTaP-wIPV maintain protective antibody levels against diphtheria, tetanus, pertussis, and poliovirus up to 6 years of age in children?
Observational (n=47)
Yes
Does primary immunization with DTaP-wIPV maintain protective antibody levels against diphtheria, tetanus, pertussis, and poliovirus up to 6 years of age in children?
Antibody levels against pertussis toxin decline rapidly within 3 years after primary DTaP-wIPV vaccination, suggesting the need for an additional preschool booster.
Faster-than-expected DTaP-wIPV antibody waning post-booster may signal surveillance needs; leaves open optimal childhood revaccination timing.
A follow-up serological study was conducted involving 47 subjects who received 4 doses of diphtheria and tetanus toxoids, combined with the acellular pertussis vaccine (DTaP) together with Salk-type inactivated polio vaccine (DTaP-wIPV), until 6 years of age. All antibody levels declined more rapidly than expected within 3 years after the completion of primary vaccination with the 4th booster dose, and titers persisted until 6 years of age. The positive rate of the IgG antibody against pertussis toxin (PT) was 31.9% (15/47) at 4 years of age, 41.0% (16/39) at 5 years of age, and 40.5% (15/37) at 6 years of age. A significant increase in anti-PT antibodies was observed in 6 subjects, suggesting subclinical infection. Positive rates of antibodies against other targets did not decrease; however, titers of neutralizing antibodies against poliovirus type III decreased in a few subjects. These data suggest the need for an additional preschool booster immunization using DTaP-wIPV.
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Nakayama et al. (2018) conducted an observational in Vaccine-acquired immunity against diphtheria, tetanus, pertussis, and poliovirus (n=47). DTaP-wIPV was evaluated on Positive rate of IgG antibody against pertussis toxin (PT) at 4 years of age. Following primary immunization with 4 doses of DTaP-wIPV, the positive rate of IgG antibodies against pertussis toxin declined to 31.9% at 4 years of age, indicating waning immunity and suggesting the need for a preschool booster.
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