Key result
Children with septic shock had significantly elevated brain natriuretic peptide levels on admission (median 115 pg/mL) compared with healthy (9 pg/mL) and critically ill controls (10 pg/mL; p<0.0001).
Why the study?
Does brain natriuretic peptide level correlate with severity of illness and myocardial dysfunction in children with septic shock?
Observational (n=30)
No
Does brain natriuretic peptide level correlate with severity of illness and myocardial dysfunction in children with septic shock?
Brain natriuretic peptide is significantly elevated in children with septic shock, particularly those with cold shock, and correlates with both illness severity and myocardial dysfunction.
Elevated BNP may signal myocardial dysfunction in pediatric septic shock; hypothesis-generating for severity stratification and requires prospective validation.
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Domico et al. (2008) conducted an observational in septic shock (n=30). Septic shock vs. Healthy children and critically ill children without infection was evaluated on Brain natriuretic peptide levels on admission (p=< 0.0001). Children with septic shock had significantly elevated brain natriuretic peptide levels on admission (median 115 pg/mL) compared with healthy (9 pg/mL) and critically ill controls (10 pg/mL; p<0.0001).
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