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Co(II) complexes of H2N-Xaa-Gly-His-CONH2 peptides (Xaa = Gly or Lys) mediate DNA cleavage upon their oxidation to Co(III)·Xaa-Gly-His with ambient dioxygen and subsequent irradiation. DNA cleavage does not appear to occur through diffusible radical formation but, more likely, through a DNA-bound metallopeptide that produces locally-reactive hydroxyl radicals. These data suggest a method for activating metallopeptides that does not require the addition of exogenous chemical oxidants or reductants.
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Ananias et al. (1997) studied this question.
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